Serotonin Franchise FDD, Costs & Fees (2025)

KEY FRANCHISE STATS

All you need to know about this franchise in a snapshot

Franchisees

?

2
+
n.a.
n.a.
Investment required

?

$666,000 - $1,363,000
Revenue (AUV)

?

$2,067,000
Undisclosed
Pro
+
n.a.
+
xx%
-xx%
n.a.
Initial franchise fee

?

$59,000
Royalty fees

?

6.00%
+
$7,500 per month + 2%
Operating Profit

?

n.a.

Pro
Franchisees

?

2
+
n.a.
n.a.
Investment required

?

$666,000 - $1,363,000
Franchise fee

?

$59,000
Royalty fees

?

6.00%
+
$7,500 per month + 2%
Revenue (AUV)

?

$2,067,000
Undisclosed
Pro
+
n.a.
+
xx%
-xx%
n.a.
Operating Profit

?

n.a.

Pro

Serotonin Centers: Pioneering the Future of Wellness and Longevity

Serotonin Centers is a forward-thinking health and wellness franchise focused on anti-aging, hormone optimization, weight management, immunity support, and aesthetic services. It was founded in 2021 by Eric Casaburi, the entrepreneur behind Retro Fitness.

The first location opened in Windermere, Florida, where the company is still headquartered. Serotonin began franchising the same year, branding itself as the nation's first human longevity franchise.

The franchise provides a comprehensive range of medically supervised services aimed at enhancing vitality and healthspan. Offerings include hormone replacement therapy, medical weight loss, IV therapy, red light therapy, and aesthetic treatments such as Botox and Hydrafacial.

Serotonin Centers also sell their own line of nutraceuticals, skincare products, and wellness apparel, offering multiple income streams for franchisees.

What differentiates Serotonin Centers is its integrated approach that combines clinical oversight with personalized wellness coaching.

Initial investment

Here's what you would need to invest if you were to start this franchise. These costs are provided by the franchisor in the Franchise Disclosure Document.

Type of Expenditure Amount
Initial Franchise Fee$59,000
Leasehold Improvements$150,000 - $550,000
Furniture, Fixtures and Equipment$50,000 - $61,000
Rent (3 months)$15,000 - $48,000
Security Deposit$5,000 - $16,000
Signage$25,000 - $38,000
Services Equipment$195,400 - $305,400
Startup Supplies$63,694 - $71,694
Insurance Deposits and Premiums (3 months)$3,750
Business Licenses and Permits$5,000 - $11,000
Professional Fees$8,000 - $25,000
Training Expenses$2,000 - $4,500
Lease Review Fee$1,800
Call Center Service Fee (2 months)$1,990
Back Office Service Fee (1 month)$0 - $995
Grand Opening Marketing$10,000
Computers and Electronics$20,000 - $25,100
Additional Funds for 3 months$50,000 - $130,000
Total Estimated Initial Investment$665,634 - $1,363,229

Franchise Disclosure Document

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Competitors

Franchise
Franchisees
Growth
Initial fee
Investment
Revenue
Gross Profit
Operating Profit
Industry

2

+
n.a.
n.a.
No growth
New

$59,000

$666,000

-

$1,363,000

n.a.

$2,067,000

Pro

n.a.

Pro

n.a.

Pro

Healthcare

Training

Serotonin offers a structured and mandatory training program to ensure franchisees and their staff are fully prepared to operate within the franchise system. The training programs offered by the franchisor include the following:

  1. Initial Training Program: This must be completed by the franchisee (or Operating Principal) and the designated Manager before opening the franchise. The program is offered at Serotonin's headquarters, another specified location, or virtually, and is held at least quarterly. It includes instruction in general operations and clinical services, and is mandatory for operating the business.
  2. Clinical Protocols Training: Authorized Care Providers are required to complete third-party vendor training on administering Proprietary Services such as hormone and IV therapies. Completion of this training to Serotonin’s satisfaction is required before these services can be provided.
  3. Replacement and Additional Staff Training: If any trained staff leave the business, their replacements must complete the necessary management and clinical training within 30 days. Additional training is charged at $500 per person per day, plus expenses.
  4. Ongoing Training Programs: Serotonin may require periodic attendance at additional courses, seminars, or conferences. These are aimed at topics like sales techniques, inventory control, and advertising strategies, and the franchisee bears all associated costs.

Territory Protection

Serotonin grants its franchisees a defined “Approved Territory,” typically determined as a three-mile drivable radius from the approved franchise location. Within this territory, and provided the franchisee complies with the agreement terms, Serotonin agrees not to establish or authorize another franchised business.

This territory is formalized in Schedule 1 of the franchise agreement, and franchisees must refrain from soliciting business outside of it without written permission. However, the protection has significant limitations.

Serotonin retains broad rights to conduct various business operations inside and outside the Approved Territory, including selling products online, through mail order, or at non-traditional venues like trade shows or “pop-up” locations.

Number of units

2024
Franchised units

0

0

2

Company-owned units

1

1

2

Total units

1

1

4

Competitors

Weighless MD

Investment required
$114,000
-
$197,000
Franchisees
2
+
n.a.
n.a.

Gameday Men's Health

Investment required
$227,000
-
$386,000
Franchisees
15
+
n.a.
n.a.

Nutrishop Store

Investment required
$46,000
-
$252,000
Franchisees
103
+
-2%
-2%

Medi-Weightloss Franchising USA LLC

Investment required
$147,000
-
$332,000
Franchisees
76
+
3%
3%

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